Questions On Breast Cancer Progression Essay - 1213 Words

Discussion: Breast cancers mostly invade into adjacent regions and metastasize to lymph nodes and distant organs. To develop novel treatments strategies, it is essential to address factors underlying tumorgenesis, invasion and metastasis. In this study, we identified Bmi-1, S100A4 and claudin-1 as important players in breast cancer progression. The current study illustrated the expression of these markers in primary breast cancer tissues, followed by demonstrating the association between their expressions and clinicopathological features and finally addressed their role in breast cancer prognosis. Regarding Bmi-1, in our study it was expressed in 58% of breast cancer cases; nearby results were reported by other investigators in their immunohistochemical studies (Kim et al., 2004; Choi et al., 2009; Guo et al., 2011; Wang et al., 2012). Moreover, there was a significant association between Bmi-1 expression and histopathological type, tumor grade, lymphovascular invasion, nodal metastasis, distant metastasis and tumor stage. These results confirm the intimate relation between Bmi-1 and breast cancer progression leading to aggressive behavior. These correlations are similar to results observed by Guo et al., 2011; Zhang et al., 2010; Wang et al., 2012). Guo et al.,2011 observed that over 90% of the late-stage cases (stages III/IV) showed high Bmi-1 expression, whereas less than 50% of the early-stage cases (stages I/II) showed high expression. Moreover, they found that 67.1% ofShow MoreRelatedThe Treatment Of Breast Cancer1134 Words   |  5 PagesBreast cancer affects so many w omen around the world. Even with the technology and medicine we have today to treat this deadly disease, the pain a patient experiences with breast cancer is still relentless. 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